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Pyridinium salts: from synthesis to reactivity and applications
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-11-03 00:00:00 , DOI: 10.1039/c7qo00836h
Subbiah Sowmiah 1, 2, 3, 4, 5 , José M. S. S. Esperança 1, 2, 3, 4, 6 , Luís P. N. Rebelo 1, 2, 3, 4, 6 , Carlos A. M. Afonso 4, 5, 7, 8, 9
Affiliation  

Structurally diverse pyridinium salts are quite familiar structures in many natural products and bioactive pharmaceuticals. Over the centuries, these privileged scaffolds have played an intriguing role in a wide range of research topics and, thus, this review aims at highlighting the pyridinium salts in terms of their synthetic routes, reactivity and their importance as pyridinium ionic liquids, as pyridinium ylides, as anti-microbial, anti-cancer, anti-malarial and anti-cholinesterase inhibitors, as well as their applications in materials science and biological issues related to gene delivery.

中文翻译:

吡啶鎓盐:从合成到反应性及应用

在许多天然产品和生物活性药物中,结构不同的吡啶鎓盐是非常熟悉的结构。几个世纪以来,这些特权支架在广泛的研究主题中发挥了有趣的作用,因此,本综述旨在从吡啶盐的合成途径,反应性及其作为吡啶鎓离子液体,吡啶鎓碘化物的重要性方面着重介绍吡啶鎓盐。 ,作为抗微生物,抗癌,抗疟疾和抗胆碱酯酶抑制剂,以及它们在与基因传递有关的材料科学和生物学问题中的应用。
更新日期:2017-11-23
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