Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions,Analyst

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Rapid, portable detection of endocrine disrupting chemicals through ligand-nuclear hormone receptor interactions
Analyst ( IF 3.6 ) Pub Date : 2017-11-15 00:00:00 , DOI: 10.1039/c7an01540b
J. Porter Hunt _{1,

2,

3,

4} , Song-Min Schinn _{1,

2,

3,

4} , Matthew D. Jones _{1,

2,

3,

4} , Bradley C. Bundy _{1,

2,

3,

4}

Affiliation

Endocrine disrupting chemicals (EDC) are structurally diverse compounds that can interact with nuclear hormone receptors, posing significant risk to human and ecological health. Unfortunately, many conventional biosensors have been too structure-specific, labor-intensive or laboratory-oriented to detect broad ranges of EDC effectively. Recently, several technological advances are providing more rapid, portable, and affordable detection of endocrine-disrupting activity through ligand-nuclear hormone receptor interactions. Here, we overview these recent advances applied to EDC biosensors – including cell lyophilization, cell immobilization, cell-free systems, smartphone-based signal detection, and improved competitive binding assays.

中文翻译：

通过配体-核激素受体相互作用快速便携式检测内分泌干扰物

内分泌干扰化学物质（EDC）是结构多样的化合物，可以与核激素受体相互作用，对人类和生态健康构成重大风险。不幸的是，许多传统的生物传感器过于结构化，劳动强度大或面向实验室，无法有效地检测各种EDC。近来，一些技术进步通过配体-核激素受体相互作用提供了更快速，便携式和负担得起的内分泌干扰活性检测。在这里，我们概述了应用于EDC生物传感器的这些最新进展-包括细胞冻干，细胞固定，无细胞系统，基于智能手机的信号检测以及改进的竞争结合测定。

更新日期：2017-11-23

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