Bleomycin Can Cleave an Oncogenic Noncoding RNA,ChemBioChem

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Bleomycin Can Cleave an Oncogenic Noncoding RNA
ChemBioChem ( IF 2.6 ) Pub Date : 2017-11-22 03:31:34 , DOI: 10.1002/cbic.201700581
Alicia J. Angelbello ₁ , Matthew D. Disney ₁

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Aiming for RNA targets? Analysis of RNA cleavage by bleomycin A5 revealed a preference for purine-rich sequences, specifically AU base pairs. Bleomycin A5 cleaved an oncogenic noncoding RNA containing these sequences in cells, thus suggesting that noncoding RNAs might be targets for certain anticancer compounds.

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