Preparation of Functionalized Diaryl- and Diheteroaryllanthanum Reagents by Fast Halogen–Lanthanum Exchange,Angewandte Chemie International Edition

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Preparation of Functionalized Diaryl- and Diheteroaryllanthanum Reagents by Fast Halogen–Lanthanum Exchange
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-22 11:06:37 , DOI: 10.1002/anie.201709553
Andreas D. Benischke ₁ , Lucile Anthore-Dalion ₁ , Guillaume Berionni ₁ , Paul Knochel ₁

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Lanthanum as a lithium alternative: Aryl and heteroaryl halides (X=Br, I) undergo a fast and convenient halogen–lanthanum exchange with nBu₂LaMe, which leads to functionalized diaryl- and diheteroaryllanthanum derivatives. Trapping reactions with ketones, aldehydes, or amides proceeded smoothly at −50 °C, affording polyfunctionalized alcohols and carbonyl derivatives.

中文翻译：

快速卤素-镧交换可制备功能化的二芳基和二杂芳基镧试剂

镧作为锂的替代品：芳基和杂芳基卤化物（X = Br，I）与n Bu ₂ LaMe进行快速便捷的卤素-镧交换，从而生成功能化的二芳基和二杂芳基镧衍生物。与酮，醛或酰胺的诱捕反应在-50°C下顺利进行，得到多官能化的醇和羰基衍生物。

更新日期：2017-11-22

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