Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp2)−H Bonds: Access to Substituted 1H-Indenes,Angewandte Chemie International Edition

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Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp2)−H Bonds: Access to Substituted 1H-Indenes
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-22 04:18:54 , DOI: 10.1002/anie.201709375
Qi Zhou ₁ , Shichao Li ₁ , Yan Zhang ₁ , Jianbo Wang _{1,

2}

Affiliation

Get into vinyl! A rhodium(II)- or copper(I)-catalyzed formal carbene insertion into vinylic C−H bonds has been developed as a straightforward method for the synthesis of 1H-indenes with high efficiency and good functional-group compatibility (see scheme). The reaction is proposed to follow a stepwise mechanism involving nucleophilic addition of the double bond to the metal carbene and dearomatization/aromatization processes.

中文翻译：

铑（II）或铜（I）催化形式的分子内碳烯插入乙烯基C（sp2-）-H键：获得取代的1H-茚

进入乙烯基！铑（II）或铜（I）催化的正式卡宾插入乙烯基C H键中已被开发为一种高效且具有良好官能团相容性的合成1 H-茚的简单方法（请参见方案）。提出该反应遵循逐步的机制，该机制涉及将双键亲核加成至金属卡宾并进行脱芳香化/芳香化过程。

更新日期：2017-11-22

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