Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation,Chemical Communications

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Ruthenium catalyzed remote C4-selective C–H functionalisation of carbazoles via σ-activation
Chemical Communications ( IF 4.3 ) Pub Date : 2017-11-16 00:00:00 , DOI: 10.1039/c7cc07606a
Jamie A. Leitch _{1,

2,

3,

4,

5} , Callum J. Heron _{2,

4,

5,

6,

7} , Janette McKnight _{1,

2,

3,

4,

5} , Gabriele Kociok-Köhn _{2,

5,

7,

8} , Yunas Bhonoah _{7,

9,

10,

11,

12} , Christopher G. Frost _{1,

2,

3,

4,

5}

Affiliation

We report the C4-selective C–H alkylation of carbazole derivatives furnished with a pyrimidine directing group at N9. This was realized using ruthenium catalyzed σ-activation methodology, whereby C–H activation at C1 enables the interaction of this ruthenacycle, at the para position to the metal center, with tertiary alkyl radicals.

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