Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds,Chemical Communications

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Short two-armed lanthanide-binding tags for paramagnetic NMR spectroscopy based on chiral 1,4,7,10-tetrakis(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane scaffolds
Chemical Communications ( IF 4.3 ) Pub Date : 2017-11-15 00:00:00 , DOI: 10.1039/c7cc07961c
Michael D. Lee _{1,

2,

3,

4} , Matthew L. Dennis _{1,

2,

3,

4,

5} , Bim Graham _{1,

2,

3,

4} , James D. Swarbrick _{1,

2,

3,

4}

Affiliation

A new pair of enantiomeric two-armed lanthanide-binding tags have been developed for paramagnetic NMR studies of proteins. The tags produce large and significantly different paramagnetic effects to one another when bound to the same tagging site. Additionally, they are less sensitive to sample pH than our previous two-armed tag designs.

中文翻译：

基于手性1,4,7,10-四（2-羟丙基）-1,4,7,10-四氮杂环十二烷骨架的短臂式镧系元素结合标签，用于顺磁NMR光谱分析

已开发出一对新的对映体双臂镧系元素结合标签，用于蛋白质的顺磁NMR研究。当标签绑定到同一标签位置时，它们会彼此产生较大且显着不同的顺磁效应。此外，与我们以前的两臂式标签设计相比，它们对样品pH值的敏感性较低。

更新日期：2017-11-22

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