DNA-crowded enzyme complexes with enhanced activities and stabilities,Chemical Communications

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DNA-crowded enzyme complexes with enhanced activities and stabilities
Chemical Communications ( IF 4.3 ) Pub Date : 2017-11-14 00:00:00 , DOI: 10.1039/c7cc07361e
John Collins _{1,

2,

3,

4} , Ting Zhang _{1,

2,

3,

4} , Sung Won Oh _{2,

3,

4,

5} , Robert Maloney _{1,

2,

3,

4} , Jinglin Fu _{1,

2,

3,

4,

5}

Affiliation

We present a robust and simple method to prepare DNA-crowded enzyme complexes by directly assembling long DNA duplexes on the enzyme surface. DNA-crowded enzyme complexes show boosted substrate turnover numbers, and increased stabilities against various storage conditions. They could be potentially scaled up for applications in biomaterials and biotechnology.

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