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Cancer Therapy: Dual‐Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug‐Resistant Cancer Therapy (Adv. Funct. Mater. 44/2017)
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2017-11-22 , DOI: 10.1002/adfm.201770260
Pengfei Zhao 1, 2 , Weimin Yin 1, 2 , Aihua Wu 2, 3 , Yisi Tang 2, 3 , Jinyu Wang 2 , Zhenzhen Pan 2, 4 , Tingting Lin 2, 5 , Meng Zhang 2 , Binfan Chen 2 , Yifei Duan 1 , Yongzhuo Huang 1, 2
Affiliation  

A complicated mechanistic interaction exists between cancer cells and tumor microenvironments. In article number 1700403, Yongzhuo Huang and co‐workers describe a “one‐stone‐two‐birds” strategy, which uses a mannosylated albumin nanoparticulate co‐delivery system to dual‐target cancer cells and M2 macrophages via the pathways of both mannose receptors and the albumin‐binding protein SPARC. This results in M2 macrophage modulation and enhanced cytotoxicity.
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中文翻译:

癌症疗法:通过甘露糖基化白蛋白纳米粒子的仿生递送将癌细胞和M2巨噬细胞双重靶向,用于抗药性癌症疗法(Adv。Funct。Mater。44/2017)

癌细胞与肿瘤微环境之间存在复杂的机械相互作用。黄永卓及其同事在文章1700403中描述了一种“单石两鸟”策略,该策略使用甘露糖基化的白蛋白纳米微粒共同递送系统通过两个甘露糖受体的途径对双靶癌细胞和M2巨噬细胞进行转运。和白蛋白结合蛋白SPARC。这导致M2巨噬细胞调节和增强的细胞毒性。
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更新日期:2017-11-22
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