Batch–flow hybrid synthesis of the antipsychotic clozapine†,Reaction Chemistry & Engineering

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Batch–flow hybrid synthesis of the antipsychotic clozapine†
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2017-11-22 00:00:00 , DOI: 10.1039/c7re00146k
N. C. Neyt _{1,

2,

3,

4} , D. L. Riley _{1,

2,

3,

4}

Affiliation

The development of batch–flow hybrid processes is becoming an attractive prospect through which chemists can make use of the best aspects of both technologies. We have reported the implementation of an on-the-fly purification by trituration which can also be utilised to perform solvent swaps. We have demonstrated this concept through the synthesis of the antipsychotic clozapine. In addition, we report a novel means of performing a reduction of an aryl nitro group under flow conditions and an overall improved process route for the total synthesis of clozapine.

中文翻译：

抗精神病药物氯氮平的批次流式混合合成†

间歇流混合工艺的发展正成为一个有吸引力的前景，化学家可以通过它利用两种技术的最佳方面。我们已经报告了通过研磨进行即时纯化的实施方法，该方法也可用于进行溶剂交换。我们已经通过合成抗精神病药氯氮平证明了这一概念。另外，我们报告了一种新颖的方法，该方法在流动条件下进行芳基硝基的还原，并全面改善了氯氮平的合成工艺路线。

更新日期：2017-11-22

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