Supramolecular polymeric biomaterials,Biomaterials Science

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Supramolecular polymeric biomaterials
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-11-02 00:00:00 , DOI: 10.1039/c7bm00780a
Joseph L. Mann _{1,

2,

3,

4} , Anthony C. Yu _{1,

2,

3,

4} , Gillie Agmon _{2,

3,

4,

5} , Eric A. Appel _{1,

2,

3,

4,

5}

Affiliation

Polymeric chains crosslinked through supramolecular interactions—directional and reversible non-covalent interactions—compose an emerging class of modular and tunable biomaterials. The choice of chemical moiety utilized in the crosslink affords different thermodynamic and kinetic parameters of association, which in turn illustrate the connectivity and dynamics of the system. These parameters, coupled with the choice of polymeric architecture, can then be engineered to control environmental responsiveness, viscoelasticity, and cargo diffusion profiles, yielding advanced biomaterials which demonstrate rapid shear-thinning, self-healing, and extended release. In this review we examine the relationship between supramolecular crosslink chemistry and biomedically relevant macroscopic properties. We then describe how these properties are currently leveraged in the development of materials for drug delivery, immunology, regenerative medicine, and 3D-bioprinting (253 references).

中文翻译：

超分子高分子生物材料

通过超分子相互作用（方向性和可逆性非共价相互作用）交联的聚合物链构成了一类新兴的模块化和可调式生物材料。在交联中使用的化学部分的选择提供了不同的缔合热力学和动力学参数，这反过来说明了系统的连通性和动力学。然后，可以将这些参数与聚合物结构的选择相结合，以控制环境响应性，粘弹性和货物扩散曲线，从而生产出先进的生物材料，这些材料可以实现快速的剪切稀化，自我修复和扩展释放。在这篇综述中，我们研究了超分子交联化学与生物医学相关的宏观性质之间的关系。

更新日期：2017-11-22

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