Degradable and biocompatible hydrogels bearing a hindered urea bond,Biomaterials Science

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Degradable and biocompatible hydrogels bearing a hindered urea bond
Biomaterials Science ( IF 5.8 ) Pub Date : 2017-10-02 00:00:00 , DOI: 10.1039/c7bm00669a
Hanze Ying _{1,

2,

3,

4} , Jonathan Yen _{2,

3,

4,

5} , Ruibo Wang _{1,

2,

3,

4} , Yang Lai _{2,

3,

4,

6} , Jer-Luen-Aaron Hsu _{1,

2,

3,

4} , Yuhang Hu _{2,

3,

4,

6} , Jianjun Cheng _{1,

2,

3,

4}

Affiliation

A hindered urea bond (HUB), recently reported as a new type of dynamic chemical bond, can be facilely constructed by mixing an isocyanate and a hindered amine. Here, we report the use of the HUB in the design of degradable hydrogel materials for applications of stem cell encapsulation and delivery. Polyethyleneglycol (PEG) diamine was end-capped with a HUB and an allyl group in a one-pot synthesis. The resulting polymer was cross-linked to form a hydrogel under UV with the addition of a 4-arm PEG thiol and a photoinitiator. The degradation properties of the hydrogels were confirmed with NMR, GPC, weight loss, and protein release studies. We found that the degradation kinetics is dependent on the size of the N-substituents, and the one with the tert-butyl group shows complete degradation within 2 days. The new hydrogel materials were also demonstrated to be biocompatible with hMSCs, and the cell release kinetics can be facilely tuned over 5 days.

中文翻译：

带有受阻尿素键的可降解生物相容性水凝胶

最近报道，受阻脲键（HUB）是一种新型的动态化学键，可以通过混合异氰酸酯和受阻胺来轻松构建。在这里，我们报告了在设计可降解水凝胶材料中使用HUB进行干细胞封装和递送的应用。一锅合成中，聚乙二醇（PEG）二胺用HUB和烯丙基封端。在添加了4-臂PEG硫醇和光引发剂的情况下，将所得的聚合物在UV下交联以形成水凝胶。通过NMR，GPC，重量损失和蛋白质释放研究证实了水凝胶的降解特性。我们发现降解动力学取决于N-取代基的大小，而叔丁基则与N-取代基的大小有关。丁基在2天内显示出完全降解。新的水凝胶材料还被证明与hMSC具有生物相容性，并且可以在5天内轻松调节细胞释放动力学。

更新日期：2017-11-22

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