Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Functionalized Solid-State Nanopore Integrated in a Reusable Microfluidic Device for a Better Stability and Nanoparticle Detection
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-21 00:00:00 , DOI: 10.1021/acsami.7b14717
Jean Roman ₁ , Nathalie Jarroux ₁ , Gilles Patriarche ₂ , Olivier Français ₃ , Juan Pelta ₁ , Bruno Le Pioufle ₄ , Laurent Bacri ₁

Affiliation

Electrical detection based on single nanopores is an efficient tool to detect biomolecules, particles and study their morphology. Nevertheless the surface of the solid-state membrane supporting the nanopore should be better controlled. Moreover, nanopore should be integrated within microfluidic architecture to facilitate control fluid exchanges. We built a reusable microfluidic system integrating a decorated membran, rendering the drain and refill of analytes and buffers easier. This process enhances strongly ionic conductance of the nanopore and its lifetime. We highlight the reliability of this device by detecting gold nanorods and spherical proteins.

中文翻译：

集成在可重复使用的微流控设备中的功能化固态纳米孔，具有更好的稳定性和纳米颗粒检测功能

基于单个纳米孔的电检测是检测生物分子，颗粒并研究其形态的有效工具。然而，应当更好地控制支撑纳米孔的固态膜的表面。此外，应将纳米孔整合到微流控体系结构中，以利于控制流体交换。我们构建了一个可重复使用的微流体系统，该系统集成了装饰膜，从而使分析物和缓冲液的排放和重新装填变得更加容易。该过程大大增强了纳米孔的离子电导率及其寿命。我们通过检测金纳米棒和球形蛋白质突出了该设备的可靠性。

更新日期：2017-11-22

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11