Influence of Grafted Block Copolymer Structure on Thermoresponsiveness of Superparamagnetic Core-Shell Nanoparticles.,Biomacromolecules

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Influence of Grafted Block Copolymer Structure on Thermoresponsiveness of Superparamagnetic Core-Shell Nanoparticles.
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-12-06 , DOI: 10.1021/acs.biomac.7b01403
Steffen Kurzhals ₁ , Martina Schroffenegger ₁ , Noga Gal ₁ , Ronald Zirbs ₁ , Erik Reimhult ₁

Affiliation

The morphology and topology of thermoresponsive polymers have a strong impact on their responsive properties. Grafting onto spherical particles has been shown to reduce responsiveness and transition temperatures; grafting of block copolymers has shown that switchable or retained wettability of a surface or particle during desolvation of one block can take place. Here, doubly thermoresponsive block copolymers were grafted onto spherical, monodisperse, and superparamagnetic iron oxide nanoparticles to investigate the effect of thermal desolvation on spherical brushes of block copolymers. By inverting the block order, the influence of core proximity on the responsive properties of the individual blocks could be studied as well as their relative influence on the nanoparticle colloidal stability. The inner block was shown to experience a stronger reduction in transition temperature and transition enthalpy compared to the outer block. Still, the outer block also experiences a significant reduction in responsiveness due to the restricted environment in the nanoparticle shell compared to that of the free polymer state. The demonstrated pronounced distance dependence importantly implies the possibility, but also the necessity, to radially tailor polymer hydration transitions for applications such as drug delivery, hyperthermia, and biotechnological separation for which thermally responsive nanoparticles are being developed.

中文翻译：

接枝嵌段共聚物结构对超顺磁性核壳纳米粒子热响应性的影响。

热响应聚合物的形态和拓扑结构对其响应性能有很大影响。已显示接枝到球形颗粒上可降低响应性和转变温度；嵌段共聚物的接枝表明在一个嵌段的去溶剂化过程中可以发生表面或颗粒的可转换或保持润湿性。在这里，将双热响应嵌段共聚物接枝到球形、单分散和超顺磁性氧化铁纳米颗粒上，以研究热去溶剂化对嵌段共聚物球形刷的影响。通过反转块顺序，可以研究核心邻近度对各个块的响应特性的影响以及它们对纳米颗粒胶体稳定性的相对影响。与外块相比，内块显示出更强烈的转变温度和转变焓降低。尽管如此，与游离聚合物状态相比，由于纳米粒子壳中的受限环境，外部块的响应性也显着降低。所证明的明显距离依赖性重要地暗示了为诸如药物递送、热疗和正在开发热响应纳米粒子的生物技术分离等应用的径向定制聚合物水合转变的可能性，但也是必要的。与游离聚合物状态相比，由于纳米粒子壳中的受限环境，外部块的响应性也显着降低。所证明的明显距离依赖性重要地暗示了为诸如药物递送、热疗和正在开发热响应纳米粒子的生物技术分离等应用的径向定制聚合物水合转变的可能性，但也是必要的。与游离聚合物状态相比，由于纳米粒子壳中的受限环境，外部块的响应性也显着降低。所证明的明显距离依赖性重要地暗示了为诸如药物递送、热疗和正在开发热响应纳米粒子的生物技术分离等应用的径向定制聚合物水合转变的可能性，但也是必要的。

更新日期：2017-11-21

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