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Nanopatterned Bulk Metallic Glass Biosensors
ACS Sensors ( IF 8.2 ) Pub Date : 2017-11-22 00:00:00 , DOI: 10.1021/acssensors.7b00455 Emily R. Kinser 1 , Jagannath Padmanabhan , Roy Yu 1 , Sydney L. Corona , Jinyang Li , Sagar Vaddiraju 2 , Allen Legassey 2 , Ayomiposi Loye , Jenna Balestrini , Dawson A. Solly , Jan Schroers , André D. Taylor , Fotios Papadimitrakopoulos 2, 3 , Raimund I. Herzog , Themis R. Kyriakides
ACS Sensors ( IF 8.2 ) Pub Date : 2017-11-22 00:00:00 , DOI: 10.1021/acssensors.7b00455 Emily R. Kinser 1 , Jagannath Padmanabhan , Roy Yu 1 , Sydney L. Corona , Jinyang Li , Sagar Vaddiraju 2 , Allen Legassey 2 , Ayomiposi Loye , Jenna Balestrini , Dawson A. Solly , Jan Schroers , André D. Taylor , Fotios Papadimitrakopoulos 2, 3 , Raimund I. Herzog , Themis R. Kyriakides
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Nanopatterning as a surface area enhancement method has the potential to increase signal and sensitivity of biosensors. Platinum-based bulk metallic glass (Pt-BMG) is a biocompatible material with electrical properties conducive for biosensor electrode applications, which can be processed in air at comparably low temperatures to produce nonrandom topography at the nanoscale. Work presented here employs nanopatterned Pt-BMG electrodes functionalized with glucose oxidase enzyme to explore the impact of nonrandom and highly reproducible nanoscale surface area enhancement on glucose biosensor performance. Electrochemical measurements including cyclic voltammetry (CV) and amperometric voltammetry (AV) were completed to compare the performance of 200 nm Pt-BMG electrodes vs Flat Pt-BMG control electrodes. Glucose dosing response was studied in a range of 2 mM to 10 mM. Effective current density dynamic range for the 200 nm Pt-BMG was 10–12 times greater than that of the Flat BMG control. Nanopatterned electrode sensitivity was measured to be 3.28 μA/cm2/mM, which was also an order of magnitude greater than the flat electrode. These results suggest that nonrandom nanotopography is a scalable and customizable engineering tool which can be integrated with Pt-BMGs to produce biocompatible biosensors with enhanced signal and sensitivity.
中文翻译：
纳米图案大块金属玻璃生物传感器
纳米图案化作为表面积增强方法具有增加生物传感器的信号和灵敏度的潜力。铂基块状金属玻璃（Pt-BMG）是一种生物相容性材料，具有有利于生物传感器电极应用的电性能，可以在相对较低的温度下于空气中进行处理，以产生纳米级的非随机形貌。本文介绍的工作采用了具有葡萄糖氧化酶功能的纳米图案Pt-BMG电极，以探索非随机性和高度可再现的纳米级表面积增强对葡萄糖生物传感器性能的影响。完成包括循环伏安法（CV）和安培伏安法（AV）的电化学测量，以比较200 nm Pt-BMG电极与Flat Pt-BMG对照电极的性能。研究了葡萄糖剂量反应，其范围为2 mM至10 mM。200 nm Pt-BMG的有效电流密度动态范围是Flat BMG对照的10-12倍。测得的纳米图案电极灵敏度为3.28μA/ cm2 / mM，也比扁平电极大一个数量级。这些结果表明，非随机纳米形貌学是一种可扩展且可定制的工程工具，可以与Pt-BMG集成以生产具有增强的信号和灵敏度的生物相容性生物传感器。
更新日期：2017-11-22
中文翻译：
纳米图案大块金属玻璃生物传感器
纳米图案化作为表面积增强方法具有增加生物传感器的信号和灵敏度的潜力。铂基块状金属玻璃（Pt-BMG）是一种生物相容性材料，具有有利于生物传感器电极应用的电性能，可以在相对较低的温度下于空气中进行处理，以产生纳米级的非随机形貌。本文介绍的工作采用了具有葡萄糖氧化酶功能的纳米图案Pt-BMG电极，以探索非随机性和高度可再现的纳米级表面积增强对葡萄糖生物传感器性能的影响。完成包括循环伏安法（CV）和安培伏安法（AV）的电化学测量，以比较200 nm Pt-BMG电极与Flat Pt-BMG对照电极的性能。研究了葡萄糖剂量反应，其范围为2 mM至10 mM。200 nm Pt-BMG的有效电流密度动态范围是Flat BMG对照的10-12倍。测得的纳米图案电极灵敏度为3.28μA/ cm2 / mM，也比扁平电极大一个数量级。这些结果表明，非随机纳米形貌学是一种可扩展且可定制的工程工具，可以与Pt-BMG集成以生产具有增强的信号和灵敏度的生物相容性生物传感器。
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