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TGF-β Gives an Air of Exclusivity to Alveolar Macrophages
Immunity ( IF 25.5 ) Pub Date : 2017-11-21 , DOI: 10.1016/j.immuni.2017.11.005
Bart N. Lambrecht

Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-β collaborates with GM-CSF to induce the master transcription factor PPARγ to drive alveolar macrophage differentiation and maintenance early in life.



中文翻译:

TGF-β使肺泡巨噬细胞具有排他性

驻留在组织中的巨噬细胞决定着它们定居的器官的发育和体内稳态。Yu等。(2017)证明,指导性细胞因子TGF-β与肺独特,与GM-CSF协同诱导主转录因子PPARγ在生命早期驱动肺泡巨噬细胞的分化和维持。

更新日期:2017-11-21
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