The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing, Published online: 22 November 2017; doi:10.1038/nrm.2017.110

Cells activate a transcriptional response known as the mitochondrial unfolded protein response (UPRmt) when mitochondrial integrity and function are impaired to promote their recovery. Recent insights into the regulation, mechanisms and functions of the UPRmt have uncovered important links to ageing and ageing-associated diseases.

中文翻译：

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线粒体UPR：衰老的机制，生理功能及其影响

线粒体UPR：衰老的机制，生理功能及其影响

线粒体UPR：机理，生理功能及其对衰老的影响，在线发布：2017年11月22日; doi：10.1038 / nrm.2017.110

当线粒体完整性和功能受损以促进其恢复时，细胞会激活称为线粒体未折叠蛋白应答（UPRmt）的转录应答。对UPRmt的法规，机制和功能的最新见解揭示了与衰老和衰老相关疾病的重要联系。