Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them, Published online: 22 November 2017; doi:10.1038/nrm.2017.103

Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function.

中文翻译：

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真核翻译调控中5'UTR mRNA的功能性结构及其如何找到

真核翻译调控中5'UTR mRNA的功能性结构及其如何找到

真核翻译调控中的功能性5'UTR mRNA结构以及如何找到它们，在线发布：2017年11月22日；doi：10.1038 / nrm.2017.103

真核mRNAs的5'非翻译区的结构通过多种机制控制帽依赖性和帽依赖性翻译起始而有助于基因调节。新的结构探测技术与诸如补偿性诱变之类的技术相结合，将有可能识别出新的结构化RNA元件并帮助阐明其功能。