(+)-Medicarpin has been synthesized asymmetrically for the first time in a linear scalable process with an overall yield of 11%. The two chiral centers were constructed in one step via condensation using a chiral oxazolidinone auxiliary. This method will likely accelerate research on medicarpin as an erythropoietin inducer for erythropoietin-deficient diseases.

中文翻译：

---

（+）-木瓜蛋白酶的全合成

（+）-Medicarpin首次在线性可扩展过程中不对称合成，总收率为11％。使用手性恶唑烷酮助剂通过缩合一步构建两个手性中心。这种方法可能会加速对麦草苷作为促红细胞生成素缺乏症疾病的促红细胞生成素诱导剂的研究。