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Cu(I)-Catalyzed Synthesis of β,γ-Unsaturated Amides
Synlett ( IF 1.7 ) Pub Date : 2017-11-22 , DOI: 10.1055/s-0036-1589135
André Isaacs , Aaron Bosse , Gregory Tsougranis , Christopher DeTroia , Francisco Tejidor

Readily available propargyl alcohols were found to be useful substrates for the copper(I)-catalyzed synthesis of β,γ-unsaturated amides. Nucleophilic attack by the alcohol on the in situ generated keten­imine followed by base-catalyzed elimination and subsequent ring opening yields the desired products under mild conditions.

中文翻译:

Cu(I)-催化合成β,γ-不饱和酰胺

发现容易获得的炔丙醇是铜 (I) 催化合成 β,γ-不饱和酰胺的有用底物。醇对原位生成的烯酮亚胺进行亲核攻击,然后碱催化消除和随后开环,在温和条件下产生所需的产物。
更新日期:2017-11-22
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