Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment

Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment, Published online: 21 November 2017; doi:10.1038/nrrheum.2017.187

Primary and secondary failure of TNF antagonists can affect treatment strategies for rheumatoid arthritis. This article discusses the implications of immunogenicity, as well as methodological problems related to the detection of antidrug antibodies and trough drug levels.

中文翻译：

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免疫原性和对TNF抑制剂的反应丧失：对类风湿关节炎治疗的意义

免疫原性和对TNF抑制剂的反应丧失：对类风湿关节炎治疗的意义

免疫原性和对TNF抑制剂反应的丧失：类风湿关节炎治疗的意义，在线发布：2017年11月21日; doi：10.1038 / nrrheum.2017.187

TNF拮抗剂的原发性和继发性衰竭会影响类风湿关节炎的治疗策略。本文讨论了免疫原性的含义，以及与抗药抗体和低谷药水平检测有关的方法学问题。