We thank Violi and colleagues for their interest in our study.¹ As noted, a growing body of evidence suggests an important involvement of Nox2 in hypertension related to a pathologically activated renin angiotensin system. This includes highly specific gene-modification studies in mouse models^1,2 as well as correlative studies in humans, such as those discussed by the authors. Taken together, these results …

中文翻译：

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Sag等人对信函的答复：“髓样细胞和内皮细胞NAPDH氧化酶2对血压的不同调节作用”

我们感谢Violi和同事对我们的研究感兴趣。¹如前所述，越来越多的证据表明Nox2参与了与病理激活的肾素血管紧张素系统有关的高血压。这包括在小鼠模型中高度特异性的基因修饰的研究^1，2在人类以及相关的研究，如那些由作者讨论。总而言之，这些结果……