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Engineering peptide ligase specificity by proteomic identification of ligation sites
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2017-11-20 , DOI: 10.1038/nchembio.2521
Amy M Weeks , James A Wells

Engineering peptide ligase specificity by proteomic identification of ligation sites

Engineering peptide ligase specificity by proteomic identification of ligation sites, Published online: 20 November 2017; doi:10.1038/nchembio.2521

A comprehensive characterization of peptide ligase specificity using proteome-derived peptide libraries enables the identification of 72 new subtiligases and their application to site-specific bioconjugation and sequencing of the cellular N terminome.


中文翻译:

通过蛋白质组学鉴定连接位点来工程化肽连接酶的特异性

通过蛋白质组学鉴定连接位点来工程化肽连接酶的特异性

通过蛋白质组学鉴定连接位点来工程化肽连接酶特异性,在线发布:2017年11月20日;doi:10.1038 / nchembio.2521

使用蛋白质组衍生肽库对肽连接酶特异性进行全面表征,可以鉴定72种新的枯草杆菌酶,并将其应用于细胞N末端组的位点特异性生物缀合和测序。
更新日期:2017-11-21
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