Structure-based inhibitors of tau aggregation

Structure-based inhibitors of tau aggregation, Published online: 20 November 2017; doi:10.1038/nchem.2889

Tau aggregation is associated with Alzheimer's disease and dozens of related dementias. Now atomic structures of the aggregation-prone segment VQIINK in repeat 2 of tau have been reported. Inhibitors designed using these structures block seeding by full-length tau better than inhibitors that target the VQIVYK aggregation segment in repeat 3.

中文翻译：

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基于结构的tau聚集抑制剂

基于结构的tau聚集抑制剂

基于结构的tau聚集抑制剂，在线发布：2017年11月20日; doi：10.1038 / nchem.2889

Tau聚集与阿尔茨海默氏病和许多相关的痴呆症有关。现在，已经报道了tau重复序列2中易于聚集的片段VQIINK的原子结构。使用这些结构设计的抑制剂比重复序列3中靶向VQIVYK聚合片段的抑制剂更好地阻止全长tau的接种。