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MnO2-Functionalized Co–P Nanocomposite: A New Theranostic Agent for pH-Triggered T1/T2 Dual-Modality Magnetic Resonance Imaging-Guided Chemo-photothermal Synergistic Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acsami.7b10608 Longhai Jin , Jianhua Liu , Ying Tang 1 , Lanqing Cao , Tianqi Zhang , Qinghai Yuan , Yinghui Wang 2 , Hongjie Zhang 2
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acsami.7b10608 Longhai Jin , Jianhua Liu , Ying Tang 1 , Lanqing Cao , Tianqi Zhang , Qinghai Yuan , Yinghui Wang 2 , Hongjie Zhang 2
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Construction of stimuli-responsive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of cancer. Herein, we constructed a novel theranostic agent with Co–P nanocomposites as core, mesoporous silica as shell, and manganese dioxide (MnO2) nanosheets as gatekeeper, which have been employed for pH-activatable T1/T2 dual-modality magnetic resonance imaging (MRI)-guided chemotherapeutical and photothermal combination anticancer therapy in vitro and in vivo. Co–P core-enabled theranostic platform could be applied for both photothermal therapy and T2-weighted MRI in the normal circulation owing to its strong near-infrared absorbance and intrinsic magnetic properties. In the acidic environment of tumors, MnO2 cap could be dissolved into Mn2+ ions to not only realize pH-responsive on-demand drug release but also activate T1-weighted MRI contrast enhancement. Such T1/T2 dual-mode MR imaging provides further comprehensive details and accurate information for tumor diagnosis, and the on-demand chemo-photothermal synergetic therapy greatly improved the therapeutic effectiveness and effectively mitigated side effects. These findings demonstrate that Co–P@mSiO2@DOX–MnO2 are promising as pH-responsive theranostic agents for tumor diagnosis and treatment, and stimulate interest in exploration of novel stimuli-responsive theranostic nanoagents which posssess good potential for clinical application in the future.
中文翻译：
MnO 2-功能化的Co-P纳米复合材料：用于pH触发的T 1 / T 2双模态磁共振成像引导的化学-光热协同治疗的新型治疗学剂
已经证明了可以增加成像诊断的准确性并提高治疗功效的刺激响应性治疗药物纳米剂的构建对于癌症的诊断和治疗是一种有前途的方法。在本文中，我们构建了一种新型的治疗药物，以Co-P纳米复合材料为核，中孔二氧化硅为壳，二氧化锰（MnO 2）纳米片作为网守，已被用于pH激活的T 1 / T 2双峰磁共振。成像（MRI）指导的体内外化学疗法和光热联合抗癌治疗。Co-P核功能治疗平台可同时用于光热疗法和T 2MRI由于其强大的近红外吸收和固有的磁性能而在正常循环中具有较高的加权比重。在肿瘤的酸性环境中，MnO 2帽可以溶解在Mn 2+离子中，不仅可以实现pH响应的按需药物释放，还可以激活T 1加权MRI造影剂。这种T 1 / T 2双模MR成像为肿瘤诊断提供了更全面的细节和准确的信息，按需化学-光热协同疗法大大提高了治疗效果并有效减轻了副作用。这些发现表明，Co–P @ mSiO 2 @ DOX–MnO 2 作为用于肿瘤诊断和治疗的pH响应性治疗药物，它们有望成为一种新型药物，并激发人们对探索新型刺激响应性治疗药物纳米药物的兴趣，这种新型纳米药物有望在未来的临床应用中具有良好的潜力。
更新日期：2017-11-21
中文翻译：
MnO 2-功能化的Co-P纳米复合材料：用于pH触发的T 1 / T 2双模态磁共振成像引导的化学-光热协同治疗的新型治疗学剂
已经证明了可以增加成像诊断的准确性并提高治疗功效的刺激响应性治疗药物纳米剂的构建对于癌症的诊断和治疗是一种有前途的方法。在本文中，我们构建了一种新型的治疗药物，以Co-P纳米复合材料为核，中孔二氧化硅为壳，二氧化锰（MnO 2）纳米片作为网守，已被用于pH激活的T 1 / T 2双峰磁共振。成像（MRI）指导的体内外化学疗法和光热联合抗癌治疗。Co-P核功能治疗平台可同时用于光热疗法和T 2MRI由于其强大的近红外吸收和固有的磁性能而在正常循环中具有较高的加权比重。在肿瘤的酸性环境中，MnO 2帽可以溶解在Mn 2+离子中，不仅可以实现pH响应的按需药物释放，还可以激活T 1加权MRI造影剂。这种T 1 / T 2双模MR成像为肿瘤诊断提供了更全面的细节和准确的信息，按需化学-光热协同疗法大大提高了治疗效果并有效减轻了副作用。这些发现表明，Co–P @ mSiO 2 @ DOX–MnO 2 作为用于肿瘤诊断和治疗的pH响应性治疗药物，它们有望成为一种新型药物，并激发人们对探索新型刺激响应性治疗药物纳米药物的兴趣，这种新型纳米药物有望在未来的临床应用中具有良好的潜力。
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