CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy and Photoacoustic Imaging,ACS Applied Materials & Interfaces

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CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy and Photoacoustic Imaging
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acsami.7b14083
Guojun Chen , Ben Ma ₁ , Yuyuan Wang , Ruosen Xie , Chun Li ₂ , Kefeng Dou ₁ , Shaoqin Gong

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Cancer remains a major threat to human health due to low therapeutic efficacies of currently available cancer treatment options. Nanotheranostics, capable of simultaneous therapy and diagnosis/monitoring of diseases, has attracted increasing amounts of attention, particularly for cancer treatment. In this study, CuS-based theranostic micelles capable of simultaneous combination chemotherapy and photothermal therapy (PTT), as well as photoacoustic imaging, were developed for targeted cancer therapy. The micelle was formed by a CuS nanoparticle (NP) functionalized by thermosensitive amphiphilic poly(acrylamide-acrylonitrile)–poly(ethylene glycol) block copolymers. CuS NPs under near-infrared (NIR) irradiation induced a significant temperature elevation, thereby enabling NIR-triggered PTT. Moreover, the hydrophobic core formed by poly(acrylamide-acrylonitrile) segments used for drug encapsulation exhibited an upper critical solution temperature (UCST; ∼38 °C), which underwent a hydrophobic-to-hydrophilic transition once the temperature rose above the UCST induced by NIR-irradiated CuS NPs, thereby triggering a rapid drug release and enabling NIR-controlled chemotherapy. The CuS-based micelles conjugated with GE11 peptides were tested in an epidermal growth factor receptor-overexpressing triple-negative breast cancer model. In both two-dimensional monolayer cell and three-dimensional multicellular tumor spheroid models, GE11-tagged CuS-based micelles under NIR irradiation, enabling the combination chemotherapy and PTT, exhibited the best therapeutic outcome due to a synergistic effect. These CuS-based micelles also displayed a good photoacoustic imaging ability under NIR illumination. Taken together, this multifunctional CuS-based micelle could be a promising nanoplatform for targeted cancer nanotheranostics.

中文翻译：

用于近红外控制的联合化疗、光热疗法和光声成像的 CuS 治疗诊断胶束

由于目前可用的癌症治疗方案的治疗效果较低，癌症仍然是对人类健康的主要威胁。纳米治疗学能够同时治疗和诊断/监测疾病，引起了越来越多的关注，特别是在癌症治疗方面。在这项研究中，开发了基于 CuS 的治疗诊断胶束，能够同时联合化疗和光热疗法 (PTT) 以及光声成像，用于靶向癌症治疗。该胶束由热敏两亲性聚（丙烯酰胺-丙烯腈）-聚（乙二醇）嵌段共聚物功能化的 CuS 纳米颗粒（NP）形成。 CuS NP 在近红外 (NIR) 照射下引起显着的温度升高，从而实现 NIR 触发的 PTT。此外，用于药物包封的聚（丙烯酰胺-丙烯腈）片段形成的疏水核心表现出上临界溶液温度（UCST；〜38°C），一旦温度升至高于UCST诱导的温度，就会发生疏水性到亲水性的转变。近红外辐射的 CuS 纳米颗粒，从而触发药物快速释放并实现近红外控制的化疗。在表皮生长因子受体过表达三阴性乳腺癌模型中测试了与 GE11 肽缀合的 CuS 胶束。在二维单层细胞和三维多细胞肿瘤球体模型中，在近红外辐射下，GE11标记的CuS基胶束能够实现联合化疗和PTT，由于协同效应，表现出最佳的治疗效果。这些 CuS 基胶束在近红外照明下也表现出良好的光声成像能力。总而言之，这种多功能 CuS 基胶束可能成为用于靶向癌症纳米治疗的有前途的纳米平台。

更新日期：2017-11-20

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