Nanocolloidosomes with Selective Drug Release for Active Tumor-Targeted Imaging-Guided Photothermal/Chemo Combination Therapy,ACS Applied Materials & Interfaces

当前位置： X-MOL 学术 › ACS Appl. Mater. Interfaces › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Nanocolloidosomes with Selective Drug Release for Active Tumor-Targeted Imaging-Guided Photothermal/Chemo Combination Therapy
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acsami.7b14796
Hang Hu ₁ , Chen Xiao ₁ , Honglian Wu ₁ , Yihui Li ₁ , Qing Zhou ₁ , Yuxiang Tang ₁ , Chan Yu ₁ , Xiangliang Yang ₁ , Zifu Li _{1,

2}

Affiliation

Selective drug release is highly desirable for photothermal/chemo combination therapy when two or even more theranostic agents are encapsulated together within the same nanocarrier. A conventional nanocarrier can hardly achieve this goal. Herein, doxorubicin and indocyanine green (DOX/ICG)-loaded nanocolloidosomes (NCs), with selective drug release, were fabricated as a novel multifunctional theranostic nanoplatform for photothermal/chemo combination therapy. Templating from galactose-functionalized hydroxyethyl starch-polycaprolactone (Gal-HES-PCL) nanoparticles-stabilized Pickering emulsions, the resultant DOX/ICG@Gal-HES-PCL NCs had a diameter of around 140 nm and showed an outstanding tumor-targeting ability, preferable tumor penetration capability, and promotion of photothermal effect. Moreover, these NCs can be used for NIR fluorescence imaging and thus render real-time imaging of solid tumors with high contrast. Collectively, such NCs achieved the best in vivo antitumor efficacy combined with laser irradiation compared with DOX/ICG@HES-PCL NCs and DOX/ICG mixture. These NCs are valuable for active tumor-targeted imaging-guided combination therapy against liver cancer and potentially other diseases.

中文翻译：

具有选择性药物释放的纳米胶体，用于主动肿瘤靶向成像引导的光热/化学联合疗法

当两种或什至更多种治疗药物一起被封装在同一纳米载体中时，选择性释放药物对于光热/化学联合疗法是非常需要的。常规的纳米载体几乎不能实现该目标。在这里，阿霉素和吲哚菁绿（DOX / ICG）负载的纳米胶体（NCs），具有选择性的药物释放，被制造为用于光热/化学联合疗法的新型多功能治疗学纳米平台。以半乳糖官能化的羟乙基淀粉-聚己内酯（Gal-HES-PCL）纳米颗粒稳定的Pickering乳液为模板，所得的DOX / ICG @ Gal-HES-PCL NCs的直径约为140 nm，并具有出色的肿瘤靶向能力，优选的肿瘤穿透能力，并促进光热效应。而且，这些NC可用于NIR荧光成像，从而以高对比度对实体瘤进行实时成像。总的来说，与DOX / ICG @ HES-PCL NCs和DOX / ICG混合物相比，此类NCs在激光照射下达到了最佳的体内抗肿瘤功效。这些NCs对于针对肝癌和潜在其他疾病的以肿瘤为靶点的主动影像引导联合治疗非常有价值。

更新日期：2017-11-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11