Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Photoluminescent polyphosphazene nanoparticles for in situ simvastatin delivery for improving the osteocompatibility of BMSCs
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2017-11-09 00:00:00 , DOI: 10.1039/c7tb02281f
Zhao-Hui Huang _{1,

2,

3,

4,

5} , Peng-Fei Wei _{1,

2,

3,

4,

5} , Le Jin _{1,

2,

3,

4,

5} , Xiao-Qing Hu _{5,

6,

7,

8,

9} , Qing Cai _{1,

2,

3,

4,

5} , Xiao-Ping Yang _{1,

2,

3,

4,

5}

Affiliation

Nanomedicines have found promising applications in regulating the biological behaviors of cells because of the cell endocytosis effect. To enhance the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSCs), which is one of the key issues in relation to bone regeneration, a biodegradable simvastatin-bearing polyphosphazene prodrug was synthesized and made into nanoparticles (NPs). At the same time, photoluminescent tryptophan ethyl ester and hydrolyzable glycine ethyl ester were introduced as co-substituted side groups onto the polyphosphazene backbone. The resultant polymer, poly(simvastatin-co-ethyl tryptophanato-co-ethyl glycinato)phosphazene (PTGP-SIM), displayed the expected features of photoluminescence, degradability and sustained SIM release. Endocytosis of PTGP-SIM NPs by BMSCs and the location of internalized NPs, were visualized via the inherent photoluminescence features of PTGP-SIM. Thus, simvastatin was released inside the cells directly along with polymer degradation and could play a role in promoting osteogenic differentiation efficiently at quite a low local concentration. From the results, the present study suggested a very promising biomaterial for use as a flexible and functional carrier for bioactive components, which could find wide applications in relation to tissue regeneration.

中文翻译：

用于现场辛伐他汀递送的光致发光聚磷腈纳米颗粒可改善BMSC的骨相容性

由于细胞内吞作用，纳米药物在调节细胞的生物学行为中发现了有前途的应用。为了增强骨髓间充质基质细胞（BMSCs）的成骨分化能力，这是与骨再生有关的关键问题之一，合成了一种可生物降解的含辛伐他汀的聚磷腈前药，并将其制成纳米颗粒（NPs）。同时，将光致发光的色氨酸乙酯和可水解的甘氨酸乙酯作为共取代的侧基引入到聚磷腈主链上。所得的聚合物，聚（辛伐他汀-共-乙基色氨酸-co-乙基甘氨酰）磷腈（PTGP-SIM）表现出预期的光致发光，可降解性和SIM持续释放的特征。骨髓基质细胞PTGP-SIM NP的内吞作用和内在纳米粒子的位置，显现通过PTGP-SIM固有的光致发光特性。因此，辛伐他汀与聚合物降解一起直接在细胞内释放，并且可以在相当低的局部浓度下有效地促进成骨细胞分化。从结果来看，本研究提出了一种非常有前途的生物材料，可用作生物活性成分的柔性和功能性载体，可以在组织再生方面找到广泛的应用。

更新日期：2017-11-21

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11