The catalytic conversion of amides to ketones is highly desirable yet challenging in organic synthesis. We herein report the first Ni/bis-NHC-catalyzed cross-coupling of N-acylpyrrole-type amides with arylboronic esters to obtain diarylketones. This method is facilitated by a new chelating bis-NHC ligand. The reaction tolerates diverse functional groups on both arylamide and arylboronic ester partners including sensitive ester and ketone groups.

中文翻译：

---

Ni- N-酰基吡咯型酰胺与有机硼试剂的镍催化交叉偶联反应

酰胺向酮的催化转化是非常需要的，但是在有机合成中具有挑战性。我们在此报道了N-酰基吡咯型酰胺与芳基硼酸酯的第一次Ni /双-NHC催化的交叉偶联，以获得二芳基酮。新的螯合双-NHC配体促进了该方法。该反应耐受芳基酰胺和芳基硼酸酯伙伴上的各种官能团，包括敏感的酯基和酮基。