pH-Responsive, Amphiphilic Core–Shell Supramolecular Polymer Brushes from Cyclic Peptide–Polymer Conjugates,ACS Macro Letters

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pH-Responsive, Amphiphilic Core–Shell Supramolecular Polymer Brushes from Cyclic Peptide–Polymer Conjugates
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acsmacrolett.7b00728
Sophie C Larnaudie ₁ , Johannes C Brendel _{1,

2} , Katrina A Jolliffe ₃ , Sébastien Perrier _{1,

2,

4}

Affiliation

The synthesis and self-assembly of pH-responsive, amphiphilic cyclic peptide–polymer conjugates are described. The design relies on the introduction of a poly(2-(diisopropylamino)ethyl methacrylate) (pDPA) block between the cyclic peptide and a hydrophilic block. These conjugates are disassembled and protonated at low pH but assemble into core–shell nanotubes at physiological pH, as determined by a combination of titration experiments and scattering techniques.

中文翻译：

来自环状肽-聚合物偶联物的 pH 响应型两亲核壳超分子聚合物刷

描述了 pH 响应的两亲性环肽-聚合物偶联物的合成和自组装。该设计依赖于在环肽和亲水性嵌段之间引入聚（2-（二异丙基氨基）甲基丙烯酸乙酯）（pDPA）嵌段。这些结合物在低 pH 值下被分解和质子化，但在生理 pH 值下组装成核壳纳米管，这是通过滴定实验和散射技术的组合确定的。

更新日期：2017-11-20

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