Molecular Tension Probes for Imaging Forces at the Cell Surface,Accounts of Chemical Research

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Molecular Tension Probes for Imaging Forces at the Cell Surface
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-11-21 00:00:00 , DOI: 10.1021/acs.accounts.7b00305
Yang Liu ₁ , Kornelia Galior ₁ , Victor Pui-Yan Ma ₁ , Khalid Salaita _{1,

2}

Affiliation

Mechanical forces are essential for a variety of biological processes ranging from transcription and translation to cell adhesion, migration, and differentiation. Through the activation of mechanosensitive signaling pathways, cells sense and respond to physical stimuli from the surrounding environment, a process widely known as mechanotransduction. At the cell membrane, many signaling receptors, such as integrins, cadherins and T- or B-cell receptors, bind to their ligands on the surface of adjacent cells or the extracellular matrix (ECM) to mediate mechanotransduction. Upon ligation, these receptor–ligand bonds transmit piconewton (pN) mechanical forces that are generated, in part, by the cytoskeleton. Importantly, these forces expose cryptic sites within mechanosensitive proteins and modulate the binding kinetics (on/off rate) of receptor–ligand complexes to further fine-tune mechanotransduction and the corresponding cell behavior.

中文翻译：

分子张力探针在细胞表面的成像力

机械力对于从转录和翻译到细胞粘附，迁移和分化的各种生物学过程都是必不可少的。通过激活机械敏感信号通路，细胞可以感知并响应周围环境的物理刺激，这一过程被广泛称为机械转导。在细胞膜上，许多信号受体，例如整联蛋白，钙黏着蛋白和T细胞或B细胞受体，会与相邻细胞或细胞外基质（ECM）表面的配体结合，以介导机械转导。连接后，这些受体-配体键会传输部分由细胞骨架产生的微微网（pN）机械力。重要的，

更新日期：2017-11-21

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