Glucocorticoids (GCs) have been used clinically for decades as potent anti-inflammatory and immunosuppressive agents. Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of glucocorticoid resistance (GCR). Therefore, efforts to understand the complex mechanisms underlying GC function and GCR are ongoing. The goal is to generate new glucocorticoid receptor (GR) ligands that can dissociate anti-inflammatory from metabolic side effects and/or overcome GCR. In this review paper we discuss recent insights into GR-mediated actions in GCR and novel therapeutic strategies for acute and chronic inflammatory diseases.

中文翻译：

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糖皮质激素的治疗​​机制

数十年来，糖皮质激素 (GC) 一直作为有效的抗炎和免疫抑制剂在临床上使用。然而，它们的使用受到产生副作用的风险和糖皮质激素抵抗 (GCR) 的严重阻碍。因此，正在努力了解 GC 功能和 GCR 背后的复杂机制。目标是产生新的糖皮质激素受体 (GR) 配体，这些配体可以将抗炎作用与代谢副作用分离和/或克服 GCR。在这篇综述论文中，我们讨论了对 GCR 中 GR 介导的作用的最新见解以及针对急性和慢性炎症疾病的新治疗策略。