We read with interest the report by Cheung et al describing increased risk of gastric cancer in patients treated long-term proton pump inhibitor (PPI) after Helicobacter pylori eradication.1 On the same day, a Swedish study also reported increased risk of gastric cancer in patients having been treated long-term with PPI.2 Since cancers in general most often require decades to develop, the magnitude of the PPI-related cancer risk cannot be foreseen. For 30 years, we have worked with the role of gastrin and the risk of PPI treatment with respect to gastric cancer and published more than 200 papers and letters in this field. However, our publications have for one reason or the other been overseen and not discussed. On the other hand, since we always have concluded that PPI treatment in the long term would cause gastric cancer, it is strange that producers of PPIs have not done studies to dismiss our results. However, the …

中文翻译：

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质子泵抑制剂和胃癌：期待已久的副作用终于在人体中也有报道

我们饶有兴趣地阅读了 Cheung 等人的报告，该报告描述了根除幽门螺杆菌后接受长期质子泵抑制剂 (PPI) 治疗的患者患胃癌的风险增加。 1 同一天，瑞典的一项研究也报告了长期接受 PPI 治疗的患者。2 由于癌症通常需要数十年才能发展，因此无法预测 PPI 相关癌症风险的程度。30 年来，我们一直致力于研究胃泌素的作用和 PPI 治疗对胃癌的风险，并在该领域发表了 200 多篇论文和信件。但是，出于某种原因，我们的出版物受到监督而不是讨论。另一方面，既然我们一直认为长期PPI治疗会导致胃癌，奇怪的是，生产者价格指数的生产者没有进行研究来否定我们的结果。然而 …