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Expression Atlas: gene and protein expression across multiple studies and organisms
Nucleic Acids Research ( IF 14.9 ) Pub Date : 2017-11-20 , DOI: 10.1093/nar/gkx1158
Irene Papatheodorou 1 , Nuno A Fonseca 1 , Maria Keays 1 , Y Amy Tang 1 , Elisabet Barrera 1 , Wojciech Bazant 1 , Melissa Burke 1 , Anja Füllgrabe 1 , Alfonso Muñoz-Pomer Fuentes 1 , Nancy George 1 , Laura Huerta 1 , Satu Koskinen 1 , Suhaib Mohammed 1 , Matthew Geniza 2 , Justin Preece 2 , Pankaj Jaiswal 2 , Andrew F Jarnuczak 1 , Wolfgang Huber 1 , Oliver Stegle 1 , Juan Antonio Vizcaino 1 , Alvis Brazma 1 , Robert Petryszak 1
Affiliation  

Expression Atlas (http://www.ebi.ac.uk/gxa) is an added value database that provides information about gene and protein expression in different species and contexts, such as tissue, developmental stage, disease or cell type. The available public and controlled access data sets from different sources are curated and re-analysed using standardized, open source pipelines and made available for queries, download and visualization. As of August 2017, Expression Atlas holds data from 3,126 studies across 33 different species, including 731 from plants. Data from large-scale RNA sequencing studies including Blueprint, PCAWG, ENCODE, GTEx and HipSci can be visualized next to each other. In Expression Atlas, users can query genes or gene-sets of interest and explore their expression across or within species, tissues, developmental stages in a constitutive or differential context, representing the effects of diseases, conditions or experimental interventions. All processed data matrices are available for direct download in tab-delimited format or as R-data. In addition to the web interface, data sets can now be searched and downloaded through the Expression Atlas R package. Novel features and visualizations include the on-the-fly analysis of gene set overlaps and the option to view gene co-expression in experiments investigating constitutive gene expression across tissues or other conditions.

中文翻译:

表达图谱:跨多个研究和生物体的基因和蛋白质表达

表达图谱 ( http://www.ebi.ac.uk/gxa ) 是一个增值数据库,提供不同物种和环境(例如组织、发育阶段、疾病或细胞类型)中基因和蛋白质表达的信息。来自不同来源的可用公共和受控访问数据集使用标准化的开源管道进行整理和重新分析,并可供查询、下载和可视化。截至 2017 年 8 月,Expression Atlas 拥有来自 33 个不同物种的 3,126 项研究的数据,其中 731 项来自植物。来自大规模 RNA 测序研究(包括 Blueprint、PCAWG、ENCODE、GTEx 和 HipSci)的数据可以彼此相邻地可视化。在表达图谱中,用户可以查询感兴趣的基因或基因集,并在本构或差异背景下探索它们在物种、组织、发育阶段之间或内部的表达,代表疾病、状况或实验干预的影响。所有处理后的数据矩阵都可以以制表符分隔格式或 R 数据形式直接下载。除了 Web 界面之外,现在还可以通过 Expression Atlas R 包搜索和下载数据集。新颖的功能和可视化包括基因集重叠的即时分析,以及在研究跨组织或其他条件的组成型基因表达的实验中查看基因共表达的选项。
更新日期:2018-01-05
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