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Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity
Journal of Allergy and Clinical Immunology ( IF 14.2 ) Pub Date : 2017-11-20 , DOI: 10.1016/j.jaci.2017.10.027
Martin Wolf , Lorenz Aglas , Teresa E. Twaroch , Markus Steiner , Sara Huber , Michael Hauser , Heidi Hofer , Maria A. Parigiani , Christof Ebner , Barbara Bohle , Peter Briza , Angela Neubauer , Frank Stolz , Michael Wallner , Fatima Ferreira

In the absence of extrinsic adjuvants, purified Amb a 1 induced a strong Th2-polarized immune response in mice. This high allergenic activity seems to be linked to the allergen’s susceptibility to endolysosomal proteolysis.



中文翻译:

Amb a 1的溶酶体蛋白酶敏感性作为致敏性的决定因素

在没有外部佐剂的情况下,纯化的Amb a 1在小鼠中诱导了强烈的Th2极化免疫反应。这种高变应原活性似乎与变应原对溶酶体蛋白水解的敏感性有关。

更新日期:2017-11-20
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