A Sweet Embrace: Control of Protein–Protein Interactions by O-Linked β-N-Acetylglucosamine,Biochemistry

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A Sweet Embrace: Control of Protein–Protein Interactions by O-Linked β-N-Acetylglucosamine
Biochemistry ( IF 2.9 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acs.biochem.7b00871
Heather J. Tarbet ₁ , Clifford A. Toleman ₁ , Michael Boyce ₁

Affiliation

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a critical post-translational modification (PTM) of thousands of intracellular proteins. Reversible O-GlcNAcylation governs many aspects of cell physiology and is dysregulated in numerous human diseases. Despite this broad pathophysiological significance, major aspects of O-GlcNAc signaling remain poorly understood, including the biochemical mechanisms through which O-GlcNAc transduces information. Recent work from many laboratories, including our own, has revealed that O-GlcNAc, like other intracellular PTMs, can control its substrates’ functions by inhibiting or inducing protein–protein interactions. This dynamic regulation of multiprotein complexes exerts diverse downstream signaling effects in a range of processes, cell types, and organisms. Here, we review the literature about O-GlcNAc-regulated protein–protein interactions and suggest important questions for future studies in the field.

中文翻译：

甜蜜的拥抱：通过O-连接的β- N-乙酰氨基葡萄糖控制蛋白与蛋白质的相互作用

O-连接的β- N-乙酰氨基葡萄糖（O-GlcNAc）是数千种细胞内蛋白的关键翻译后修饰（PTM）。可逆的O-GlcNAcylation控制着细胞生理的许多方面，并且在许多人类疾病中失调。尽管具有广泛的病理生理学意义，但对O-GlcNAc信号转导的主要方面仍知之甚少，包括O-GlcNAc通过其转导信息的生化机制。许多实验室（包括我们自己的实验室）的最新工作表明，O-GlcNAc与其他细胞内PTM一样，可以通过抑制或诱导蛋白质-蛋白质相互作用来控制其底物的功能。这种对多蛋白复合物的动态调节在一系列过程，细胞类型和生物体中发挥了多种下游信号传导作用。这里，

更新日期：2017-11-20

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