Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities,Journal of Natural Products

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Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities
Journal of Natural Products ( IF 3.3 ) Pub Date : 2017-11-20 00:00:00 , DOI: 10.1021/acs.jnatprod.6b00921
Jiayuan Li ₁ , Ning Li ₁ , Xuezheng Li ₂ , Gang Chen ₁ , Cungang Wang ₁ , Bin Lin ₃ , Yue Hou ₄

Affiliation

Twenty compounds, including 14 new α-acid derivatives, a new chromone, and five known compounds, were identified from the pistillate inflorescence of Humulus lupulus (hops), and their structures were elucidated via physical data analysis. The absolute configurations of new α-acid derivatives 1–11b were determined by comparing their computed and experimental electronic circular dichroism spectra using TDDFT and NMR spectroscopic data. A putative biosynthetic pathway for the identified components was deduced. Their antineuroinflammatory effects were assayed systematically, and their structure–activity relationships are discussed briefly. Among the identified compounds, compound 14 displayed moderate inhibitory effects against nitric oxide production with an IC₅₀ value of 7.92 μM.

中文翻译：

Hum草具有抗神经炎活性的特征性α-酸衍生物

从Hum草（蛇麻草）的雌花序中鉴定出20种化合物，包括14种新的α-酸衍生物，一种新的色酮和5种已知的化合物，并通过物理数据分析阐明了它们的结构。的新的α -酸衍生物的绝对构1 - 11B通过比较它们的计算，并利用实验电子圆二色光谱TDDFT和NMR光谱数据确定。推导了所鉴定组分的假定生物合成途径。系统地分析了它们的抗神经炎作用，并简要讨论了它们的结构-活性关系。在确定的化合物中，化合物14表现出对一氧化氮产生的中等抑制作用，IC ₅₀值为7.92μM。

更新日期：2017-11-20

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