OBJECTIVE Changes in liver fatty acid metabolism are important in understanding the mechanisms of diabetes remission and metabolic changes after bariatric surgery.

RESEARCH DESIGN AND METHODS Liver fatty acid uptake (LFU), blood flow, and fat content (LFC) were measured in 25 obese subjects before bariatric surgery and 6 months after using positron emission tomography/computed tomography and MRS; 14 lean individuals served as the control subjects.

RESULTS The increased LFU in obese subjects was associated with body adiposity. LFU was reduced postoperatively but was still high compared with the control subjects. LFC was normalized. Liver blood flow (per unit volume) was higher in obese subjects than in the control subjects at baseline and was further increased postoperatively; however, the total organ blood flow was unchanged as the liver volume decreased.

CONCLUSIONS The findings suggest that in a postoperative state, intrahepatic fatty acids are not stored in the liver but are used for oxidation to provide energy. Changes in perfusion may contribute to improved liver metabolism postoperatively.

目的肝脏脂肪酸代谢的变化对于了解减肥手术后糖尿病缓解和代谢变化的机制很重要。

研究设计和方法在减肥手术之前和使用正电子发射断层扫描/计算机断层扫描和MRS后的6个月中，对25名肥胖受试者的肝脏脂肪酸摄取（LFU），血流量和脂肪含量（LFC）进行了测量。14名瘦肉个体作为对照对象。

结果肥胖受试者的LFU升高与身体肥胖有关。术后LFU降低，但与对照组相比仍较高。LFC已标准化。在基线时，肥胖受试者的肝血流量（每单位体积）高于对照组，并且术后进一步增加。然而，随着肝脏体积的减少，总器官血流量没有变化。

结论结论表明，在术后状态下，肝内脂肪酸不储存在肝脏中，而是用于氧化以提供能量。灌注的变化可能有助于术后肝脏代谢的改善。