OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants ( n = 2,326; 25–70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m−2 and impaired fasting glucose (5.6–6.9 mmol ⋅ L−1) or impaired glucose tolerance (7.8–11.0 mmol ⋅ L−1 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = −0.078 [95% CI −0.128, −0.027]), waist circumference (WC) (β = −0.177 [−0.122, −0.134]), fasting insulin (β = −0.115 [−0.158, −0.072]), 2-h glucose (β = −0.069 [−0.112, −0.025]), triglycerides (β = −0.091 [−0.138, −0.044]), and CRP (β = −0.086 [−0.127, −0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, −0.172]). Associations reported between total PA (counts ⋅ min−1), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = −0.151 [−0.194, −0.107]), WC (β = −0.179 [−0.224, −0.134]), fasting insulin (β = −0.139 [−0.183, −0.096]), 2-h glucose (β = −0.088 [−0.131, −0.045]), triglycerides (β = −0.117 [−0.162, −0.071]), and CRP (β = −0.104 [−0.146, −0.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

中文翻译：

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成年人糖尿病患者的客观测量的体育活动和久坐时间与心脏代谢危险因素相关：PREVIEW研究

目的本横断面研究的目的是检查成年前糖尿病患者的体力活动（PA），久坐时间（ST）和心脏代谢风险之间的相关性。研究设计与方法来自八个国家的参与者（n = 2,326； 25-70岁，女性67％），其BMI> 25 kg⋅m−2，并且空腹血糖受损（5.6–6.9 mmol⋅L-1）或受损葡萄糖耐量（2 h时为7.8-11.0 mmol⋅L-1）参加。七天的加速度计客观地评估了PA水平和ST。结果多元线性回归显示，中度至重度PA（MVPA）与胰岛素抵抗（HOMA-IR）（标准β= -0.078 [95％CI -0.128，-0.027]），腰围（WC）的HOMA呈负相关）（β= -0.177 [-0.122，-0.134]），空腹胰岛素（β= -0.115 [-0.158，-0.072]），2小时葡萄糖（β= -0.069 [-0.112，-0.025]），甘油三酸酯（β= -0.091 [-0.138，-0.044]）和CRP（β= -0.086 [-0.127，-0.045]）。ST与HOMA-IR（β= 0.175 [0.114，0.236]），WC（β= 0.215 [0.026，0.131]），空腹胰岛素（β= 0.155 [0.092，0.219]），甘油三酸酯（β= 0.106 [ 0.052，0.16]），CRP（β= 0.106 [0.39，0.172]），收缩压（BP）（β= 0.078 [0.026，0.131]）和舒张压（β= 0.106 [0.39，-0.172]）。报告的总PA（计数⋅min-1）与所有危险因素之间的关联性高于或高于MVPA：HOMA-IR（β= -0.151 [-0.194，-0.107]），WC（β= -0.179 [- 0.224，-0.134]），空腹胰岛素（β= -0.139 [-0.183，-0.096]），2小时葡萄糖（β= -0.088 [-0.131，-0.045]），甘油三酸酯（β= -0.117 [-0.162] ，-0.071]）和CRP（β= -0.104 [-0.146，-0.062]）。结论在患有糖尿病前期的成年人中，客观测量的PA和ST与心脏代谢风险标志物相关。总PA与MVPA至少与心脏代谢风险指标密切相关，这可能暗示一天中总PA的积累与达到MVPA强度同样重要。