Due to its versatile properties, hydroxypropyl methylcellulose (HPMC) is largely used in many applications and deeply studied in the various fields such as pharmaceuticals, biomaterials, agriculture, food, water purification. In this work, vitamin B12 loaded HPMC granules were produced to investigate their potential application as nutraceutical products. To this aim the impact of vitamin load on physico-chemical, mechanical and release properties of granules, achieved by wet granulation process, was investigated. In particular, three different loads of B12 (1%, 2.3% and 5% w/w) were assayed. Unloaded granules (used as control) and loaded granules were dried, sieved, and then the suitable fraction for practical uses, 0.45–2 mm in size, was fully characterized. Results showed that the vitamin incorporation of 5% reduced the granulation performance in the range size of 0.45–2 mm and led granules with higher porosity, more rigid and less elastic structures compared to unloaded granules and those loaded at 1% and 2.3% of B12. Vitamin release kinetics of fresh and aged granules were roughly found the same trends for all the prepared lots; however, the vitamin B12 was released more slowly when added with a load at 1% w/w, suggesting a better incorporation.

羟丙基甲基纤维素（HPMC）由于具有多种用途，因此在许多应用中得到了广泛的应用，并在诸如制药，生物材料，农业，食品，水净化等各个领域进行了深入的研究。在这项工作中，生产了负载维生素B12的HPMC颗粒，以研究其作为营养产品的潜在应用。为了这个目的，研究了通过湿法制粒过程获得的维生素负荷对颗粒的物理化学，机械和释放性能的影响。特别地，测定了三种不同的B12负载（1％，2.3％和5％w / w）。将未装载的颗粒（用作对照）和装载的颗粒进行干燥，筛分，然后将其作为实际用途的合适部分0.45–2 毫米大小，已充分表征。结果表明，加入5％的维生素会降低0.45–2  mm范围内颗粒的造粒性能，与未装载的颗粒以及分别装载1％和2.3％的B12的颗粒相比，其颗粒具有更高的孔隙率，更坚硬和更少的弹性结构。对于所有制备的批次，新鲜和陈旧颗粒的维生素释放动力学大致都发现了相同的趋势。但是，添加1％w / w的维生素B12时，其释放速度较慢，表明其掺入更好。