In this work, in order to enhance the stability, bioavailability and antioxidant activity of insoluble antioxidants used into juice, yoghourt and nutritional supplements, the oligo-hyalurosomes nano-delivery system (CRHs) based on oligo-hyaluronic acid −curcumin (oHC) polymer loaded curcumin(Cur) and resveratrol (Res) was fabricated with new nanotechnolgy. The rosy biodegradable amphiphilic oHC polymer was successfully synthesized and used to fabricate the hyalurosomes containing both Cur and Res, called CRHs. The CRHs can spontaneously self-assemble into nano-sized spherical shape of average particle size 134.5 ± 5.1 nm and Zeta potential −29.4 ± 1.2 at pH 7.4 PBS conditions. In vitro gastrointestinal release test showed a perfect stability and outstanding sustained release character. Moreover, compared to the single formulations and liposomes, CRHs showed a dose-dependent manner with a higher radical scavenging activity. Therefore, the novel CRHs nano-food manifested the hopeful properties for the new effective gastrointestinal formulation and promising new nano-food delivery system in the use of juice, yoghourt and nutritional supplements.

在这项工作中，为了提高用于果汁，酸奶和营养补品中的不溶性抗氧化剂的稳定性，生物利用度和抗氧化活性，基于寡透明质酸-姜黄素（oHC）聚合物的寡透明质体纳米递送系统（CRH）负载的姜黄素（Cur）和白藜芦醇（Res）采用了新的纳米技术。成功地合成了玫瑰色可生物降解的两亲性oHC聚合物，并将其用于制造含有Cur和Res的透明质体，称为CRH。CRH可以自发自组装成平均粒径134.5  ±  5.1  nm和Zeta电位-29.4  ±的纳米级球形 在pH 7.4 PBS条件下为1.2。体外胃肠道释放试验显示出完美的稳定性和出色的持续释放特性。此外，与单一制剂和脂质体相比，CRHs表现出剂量依赖性，具有更高的自由基清除活性。因此，新型CRHs纳米食品在果汁，酸奶和营养补品的使用中表现出了对于新型有效胃肠道制剂的希望性质，并有望为新型纳米食品递送系统带来希望。