Cancer cells rewire metabolism to scavenge nutrients and waste products Cancer cells are thought to undergo metabolic rewiring to scavenge waste products and recycle them as building blocks for growth. On page 941 of this issue, Spinelli et al. (1) report that ammonia could be recycled through glutamate dehydrogenase (GDH)–mediated reductive amination of α-ketoglutarate to produce the amino acid glutamate that, in turn, is converted to other amino acids such as aspartate and proline for biomass production (see the figure). This intriguing evidence of nitrogen fixation by breast cancer cells is reminiscent of nitrogen fixation in bacteria, yeast, and plants mediated by biochemical systems that evolved to harness nitrogen from the atmosphere for amino acid biosynthesis and biomass accumulation (2).

中文翻译：

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为癌细胞疯狂喂食

癌细胞重新连接代谢以清除营养物质和废物 癌细胞被认为经过代谢重新布线以清除废物并将其作为生长的基石进行回收。在本期第 941 页，Spinelli 等人。(1) 报告说氨可以通过谷氨酸脱氢酶 (GDH) 介导的 α-酮戊二酸还原胺化反应生成氨基酸谷氨酸，然后再转化为其他氨基酸，如天冬氨酸和脯氨酸用于生物质生产（见图）。乳腺癌细胞固氮的这一有趣证据让人联想到细菌、酵母和植物中的固氮作用，由生化系统介导，这些系统进化为利用大气中的氮进行氨基酸生物合成和生物量积累 (2)。