In this work, a TFB (poly[(9,9-dioctylfluorenyl-2,7-diyl)-co-(4,4′-(N-(4-s-butylphenyl)diphenylamine)]) sensor with a cylindrical nanopore structure exhibits a high sensitivity to ammonia in ppb-regime. The lifetime and sensitivity of the TFB sensor were studied and compared to those of P3HT (poly(3-hexylthiophene)), NPB (N,N′-di(1-naphthyl)-N,N′-diphenyl-(1,1′-biphenyl)-4,4′-diamine), and TAPC (4,4′-cyclohexylidenebis[N,N-bis(4-methylphenyl) benzenamine]) sensors with the same cylindrical nanopore structures. The TFB sensor outstands the others in sensitivity and lifetime and it shows a sensing response (current variation ratio) of 13% to 100 ppb ammonia after 64 days of storage in air. A repeated sensing periods testing and a long-term measurement have also been demonstrated for the test of robustness. The performance of the TFB sensor is stable in both tests, which reveals that the TFB sensor can be utilized in our targeting clinical trials. In the last part of this work, we study the change of ammonia concentration in the breath of hemodialysis (HD) patients before and after dialysis. An obvious drop of breath ammonia concentration can be observed after dialysis. The reduction of breath ammonia is also correlated with the reduction of blood urea nitrogen (BUN). A correlation coefficient of 0.82 is achieved. The result implies that TFB sensor may be used as a real-time and low cost breath ammonia sensor for the daily tracking of hemodialysis patients.

中文翻译：

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使用寿命更长的有机气体传感器，可用于血液透析患者的呼吸性氨气检测

在这项工作中，TFB（聚[（9,9-二辛基芴-2,7-二基） -共- （4,4' - （ñ - （4-小号丁基苯基）二苯胺）]具有圆柱形纳米孔）传感器结构对ppb态氨具有很高的敏感性，研究了TFB传感器的寿命和灵敏度，并将其与P3HT（聚（3-己基噻吩）），NPB（N，N'-二（1-萘基））进行了比较。 - ñ，ñ N'-二苯基（1,1'-联苯基）-4,4'-二胺），和TAPC（4,4'- cyclohexylidenebis [ ñ，ñ-双（4-甲基苯基）苯并胺]）传感器具有相同的圆柱纳米孔结构。TFB传感器在灵敏度和寿命方面均优于其他传感器，在空气中存储64天后，其氨气（100 ppb）显示13％的感测响应（电流变化率）。重复的感测周期测试和长期测量也已被证明可用于鲁棒性测试。TFB传感器的性能在两个测试中均稳定，这表明TFB传感器可用于我们的靶向临床试验。在这项工作的最后一部分，我们研究了透析前后血液透析（HD）患者呼吸中氨气浓度的变化。透析后可观察到明显的呼吸氨浓度下降。呼吸氨的减少还与血液尿素氮（BUN）的减少相关。相关系数为0.82。结果表明，TFB传感器可用作实时，低成本的呼吸氨传感器，用于血液透析患者的日常跟踪。