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Aggregation-Induced Emission-Based Chemodosimeter Approach for Selective Sensing and Imaging of Hg(II) and Methylmercury Species
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-11-17 00:00:00 , DOI: 10.1021/acs.analchem.7b02663 Amrita Chatterjee 1 , Mainak Banerjee 1 , Dipratn G. Khandare 1 , Ram U. Gawas 1 , Starlaine C. Mascarenhas 1 , Anasuya Ganguly 1 , Rishabh Gupta 1 , Hrishikesh Joshi 1
Analytical Chemistry ( IF 6.7 ) Pub Date : 2017-11-17 00:00:00 , DOI: 10.1021/acs.analchem.7b02663 Amrita Chatterjee 1 , Mainak Banerjee 1 , Dipratn G. Khandare 1 , Ram U. Gawas 1 , Starlaine C. Mascarenhas 1 , Anasuya Ganguly 1 , Rishabh Gupta 1 , Hrishikesh Joshi 1
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Methylmercury (CH3Hg+) is the common form of organic mercury and is more toxic than its inorganic or elemental forms. Mercury is emanated in the course of various natural events and human activities and converts to methylmercury by anaerobic organisms. CH3Hg+ are ingested by fish and subsequently bioaccumulated in their tissue and, eventually, enter the human diet, causing serious health issues. Therefore, selective and sensitive detection of bioaccumulated CH3Hg+ in fish samples is essential. Herein, the development of a simple, highly sensitive and selective aggregation-induced emission (AIE)-based turn-on probe for both inorganic mercury ions and organicmercury species is reported. The probe’s function is based on mercury ion-promoted transmetalation reaction of aryl boronic acid. The probe, a tetraphenylethylene (TPE)–monoboronic acid (1), was successfully utilized for AIE-based fluorescence imaging study on methylmercury-contaminated live cells and zebrafish for the first time. Both Hg(II) and CH3Hg+ ensued a fast transmetalation of TPE–boronic acid causing drastic reduction in the solubility of the resulting product (TPE–HgCl/TPE–HgMe) in the working solvent system. At the dispersed phase, the aggregated form of TPE–mercury ions recovers planarity because of restricted rotational freedom promoting aggregation-induced emission. Simple design, cost-effective synthesis, high selectivity, inexpensive instrumentation, fast signal transduction, and low limit of detection (0.12 ppm) are some of the key merits of this analytical tool.
中文翻译：
聚集诱导的基于化学计量学的汞（II）和甲基汞物种的选择性传感和成像方法
甲基汞（CH 3 Hg +）是有机汞的常见形式，并且比其无机或元素形式更具毒性。汞是在各种自然事件和人类活动过程中产生的，并通过厌氧生物转化为甲基汞。CH 3 Hg +被鱼摄入，随后在其组织中进行生物蓄积，并最终进入人类饮食，从而引起严重的健康问题。因此，对生物积累的CH 3 Hg +的选择性和灵敏检测在鱼类样品中至关重要。本文中，报道了针对无机汞离子和有机汞物种的简单，高度灵敏和选择性的聚集诱导发射（AIE）开启探针的开发。探针的功能基于芳基硼酸的汞离子促进的重金属化反应。探针，四苯乙烯（TPE）-单硼酸（1），首次成功地用于基于甲基丙烯酸甲酯的荧光成像研究，该研究对甲基汞污染的活细胞和斑马鱼进行了研究。Hg（II）和CH 3 Hg +随后发生TPE-硼酸的快速重金属转移，从而导致最终产物（TPE-HgCl / TPE-HgMe）在工作溶剂系统中的溶解度大大降低。在分散相中，TPE-汞离子的聚集形式恢复了平面度，因为受限制的旋转自由度促进了聚集诱导的发射。简单的设计，具有成本效益的合成，高选择性，廉价的仪器，快速的信号传导和低检测限（0.12 ppm）是该分析工具的一些关键优点。
更新日期：2017-11-19
中文翻译：
聚集诱导的基于化学计量学的汞（II）和甲基汞物种的选择性传感和成像方法
甲基汞（CH 3 Hg +）是有机汞的常见形式，并且比其无机或元素形式更具毒性。汞是在各种自然事件和人类活动过程中产生的，并通过厌氧生物转化为甲基汞。CH 3 Hg +被鱼摄入，随后在其组织中进行生物蓄积，并最终进入人类饮食，从而引起严重的健康问题。因此，对生物积累的CH 3 Hg +的选择性和灵敏检测在鱼类样品中至关重要。本文中，报道了针对无机汞离子和有机汞物种的简单，高度灵敏和选择性的聚集诱导发射（AIE）开启探针的开发。探针的功能基于芳基硼酸的汞离子促进的重金属化反应。探针，四苯乙烯（TPE）-单硼酸（1），首次成功地用于基于甲基丙烯酸甲酯的荧光成像研究，该研究对甲基汞污染的活细胞和斑马鱼进行了研究。Hg（II）和CH 3 Hg +随后发生TPE-硼酸的快速重金属转移，从而导致最终产物（TPE-HgCl / TPE-HgMe）在工作溶剂系统中的溶解度大大降低。在分散相中，TPE-汞离子的聚集形式恢复了平面度，因为受限制的旋转自由度促进了聚集诱导的发射。简单的设计，具有成本效益的合成，高选择性，廉价的仪器，快速的信号传导和低检测限（0.12 ppm）是该分析工具的一些关键优点。
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