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A biocompatible betaine-functionalized polycation for coacervation
Soft Matter ( IF 2.9 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7sm01763d Mintai P. Hwang 1, 2, 3, 4 , Xiaochu Ding 1, 2, 3, 4 , Jin Gao 4, 5, 6, 7 , Abhinav P. Acharya 4, 5, 6, 7 , Steven R. Little 4, 5, 6, 7 , Yadong Wang 1, 2, 3, 4
Soft Matter ( IF 2.9 ) Pub Date : 2017-11-10 00:00:00 , DOI: 10.1039/c7sm01763d Mintai P. Hwang 1, 2, 3, 4 , Xiaochu Ding 1, 2, 3, 4 , Jin Gao 4, 5, 6, 7 , Abhinav P. Acharya 4, 5, 6, 7 , Steven R. Little 4, 5, 6, 7 , Yadong Wang 1, 2, 3, 4
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The aqueous nature of complex coacervates provides a biologically-relevant context for various therapeutic applications. In this sense, biological applications demand a corresponding level of biocompatibility from the polyelectrolytes that participate in complex coacervation. Continued development with naturally-occurring polyelectrolytes such as heparin and chitosan underscore such aims. Herein, we design a synthetic polycation, in which betaine is conjugated to a biodegradable polyester backbone. Betaine is a naturally-occurring methylated amino acid that is ubiquitously present in human plasma. Inspired by its vast range of benefits – including but not limited to anti-inflammation, anti-cancer, anti-bacterial, anti-oxidant, protein stabilization, and cardiovascular health – we aim to impart additional functionality to a polycation for eventual use in a complex coacervate with heparin. We report on its in vitro and in vivo biocompatibility, in vitro and in vivo effect on angiogenesis, in vitro effect on microbial growth, and ability to form complex coacervates with heparin.
中文翻译：
生物相容性甜菜碱官能化聚阳离子用于凝聚
复合凝聚层的水性性质为各种治疗应用提供了生物学相关的背景。从这个意义上讲，生物学应用要求参与复杂凝聚的聚电解质具有相应水平的生物相容性。天然存在的聚电解质（例如肝素和壳聚糖）的持续开发强调了这一目标。在本文中，我们设计了一种合成的聚阳离子，其中甜菜碱与可生物降解的聚酯骨架共轭。甜菜碱是人体血浆中普遍存在的天然存在的甲基化氨基酸。受其广泛益处的启发-包括但不限于抗炎，抗癌，抗菌，抗氧化剂，蛋白质稳定，和心血管健康–我们的目标是为聚阳离子赋予其他功能，以最终与肝素复合凝聚使用。我们报告其体外和体内生物相容性，体外和体内对血管生成的影响，体外对微生物生长的影响以及与肝素形成复合凝聚层的能力。
更新日期：2017-11-17
中文翻译：
生物相容性甜菜碱官能化聚阳离子用于凝聚
复合凝聚层的水性性质为各种治疗应用提供了生物学相关的背景。从这个意义上讲，生物学应用要求参与复杂凝聚的聚电解质具有相应水平的生物相容性。天然存在的聚电解质（例如肝素和壳聚糖）的持续开发强调了这一目标。在本文中，我们设计了一种合成的聚阳离子，其中甜菜碱与可生物降解的聚酯骨架共轭。甜菜碱是人体血浆中普遍存在的天然存在的甲基化氨基酸。受其广泛益处的启发-包括但不限于抗炎，抗癌，抗菌，抗氧化剂，蛋白质稳定，和心血管健康–我们的目标是为聚阳离子赋予其他功能，以最终与肝素复合凝聚使用。我们报告其体外和体内生物相容性，体外和体内对血管生成的影响，体外对微生物生长的影响以及与肝素形成复合凝聚层的能力。
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