The metabolism of endothelial cells (ECs) has only recently been recognized as a driving force of angiogenesis. Metabolic pathways, such as glycolysis, fatty acid oxidation, and glutamine metabolism, have distinct, essential roles during vessel formation. Moreover, EC metabolism is markedly perturbed in pathologies such as cancer and diabetes. For instance, because tumor ECs increase glycolysis, lowering hyperglycolysis in tumor ECs induces therapeutic benefits in preclinical tumor models. Expanding our knowledge of how ECs alter their metabolism in disease could pave the way for novel therapeutic opportunities. In this review, we discuss the most recent insights into EC metabolism in health and disease, with emphasis on the changes in metabolism in the tumor endothelium.

内皮细胞（ECs）的代谢直到最近才被认为是血管生成的驱动力。代谢途径，例如糖酵解，脂肪酸氧化和谷氨酰胺代谢，在血管形成过程中具有独特的重要作用。而且，EC代谢在诸如癌症和糖尿病的病理中显着地受到干扰。例如，由于肿瘤EC增加了糖酵解，因此降低肿瘤EC中的高糖分解诱导了临床前肿瘤模型的治疗益处。扩大我们对ECs如何改变其疾病代谢的认识，可以为新的治疗机会铺平道路。在这篇综述中，我们讨论了有关健康和疾病中EC代谢的最新见解，重点是肿瘤内皮中新陈代谢的变化。