Parechovirus A3 (Par-A3, formerly human parechovirus 3) is an emerging viral infection of the central nervous system in children. We used an automated, homogeneous, cell based assay to identify itraconazole and posaconazole as inhibitors of Par-A3, with antiviral activity below concentrations clinically attainable in pediatric patients. Currently, there is no approved antiviral treatment for Par-A3 infection, despite numerous reports of serious Par-A3 disease in neonates and infants.

中文翻译：

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抗真菌唑类药物伊曲康唑和泊沙康唑对临床分离的副肠孤病毒 A3（小核糖核酸病毒科）表现出有效的体外抗病毒活性

副肠孤病毒 A3（Par-A3，以前称为人类副肠孤病毒 3）是一种新出现的儿童中枢神经系统病毒感染。我们使用自动化、均质、基于细胞的测定来鉴定伊曲康唑和泊沙康唑作为 Par-A3 抑制剂，其抗病毒活性低于儿科患者临床可达到的浓度。目前，尽管有大量关于新生儿和婴儿出现严重 Par-A3 疾病的报告，但尚无批准的针对 Par-A3 感染的抗病毒治疗方法。