Revealing the current source distribution along the neuronal membrane is a key step on the way to understanding neural computations, however, the experimental and theoretical tools to achieve sufficient spatiotemporal resolution for the estimation remain to be established. Here we address this problem using extracellularly recorded potentials with arbitrarily distributed electrodes for a neuron of known morphology. We use simulations of models with varying complexity to validate the proposed method and to give recommendations for experimental applications. The method is applied to in vitro data from rat hippocampus.

中文翻译：

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从细胞外记录揭示沿神经元树突树的跨膜电流分布

揭示沿神经元膜的电流源分布是理解神经计算方法的关键步骤，但是，仍需要建立实现估计所需的足够时空分辨率的实验和理论工具。在这里，我们使用具有已知形态的神经元的任意分布电极的细胞外记录电位来解决这个问题。我们使用具有不同复杂度的模型仿真来验证所提出的方法并为实验应用提供建议。该方法适用于大鼠海马的体外数据。