Revealing the current source distribution along the neuronal membrane is a key step on the way to understanding neural computations; however, the experimental and theoretical tools to achieve sufficient spatiotemporal resolution for the estimation remain to be established. Here, we address this problem using extracellularly recorded potentials with arbitrarily distributed electrodes for a neuron of known morphology. We use simulations of models with varying complexity to validate the proposed method and to give recommendations for experimental applications. The method is applied to in vitro data from rat hippocampus.

中文翻译：

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从细胞外记录揭示沿神经元树突树的跨膜电流分布

揭示沿神经元膜的电流源分布是理解神经计算的关键一步；然而，仍有待建立用于估计的足够时空分辨率的实验和理论工具。在这里，我们使用细胞外记录的电位和任意分布的电极来解决这个问题，用于已知形态的神经元。我们使用具有不同复杂性的模型模拟来验证所提出的方法并为实验应用提供建议。该方法应用于大鼠海马体的体外数据。