Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics,Angewandte Chemie International Edition

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Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2017-11-17 04:31:50 , DOI: 10.1002/anie.201707069
Claudia Guttroff ₁ , Aslihan Baykal ₁ , Huanhuan Wang ₂ , Peter Popella ₂ , Frank Kraus ₁ , Nicole Biber ₁ , Sophia Krauss ₂ , Friedrich Götz ₂ , Bernd Plietker ₁

Affiliation

A defined endo-type B PPAP library was synthesized, and the antibiotic activity against multiresistant S. aureus and various vancomycin-resistant Enterococci was evaluated. Four new compounds with high activity and low cytotoxicity were identified, indicating that the PPAP core might become a new non-peptide-based lead structure in antibiotic research. PPAP=polycyclic polyprenylated acylphloroglycinol.

中文翻译：

多环多戊烯基化酰基葡糖醇：新兴的一类非基于肽的MRSA和VRE活性抗生素

合成确定的内型B PPAP文库，并评估其对多重耐药金黄色葡萄球菌和各种耐万古霉素肠球菌的抗生素活性。鉴定出四种具有高活性和低细胞毒性的新化合物，表明PPAP核心可能成为抗生素研究中一种新的基于非肽的前导结构。PPAP =多环聚戊二酰基化酰基甘氨醇。

更新日期：2017-11-17

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